I replaced the cam, lifters, VVT, timing chain, oil pump, and eliminated the MDS system on my daughter's 2014 392 Charger (around 90,000 miles?). I used the Hellcat high volume oil pump. This was all done after losing the lifter on cylinder #2, and wiping the cam lobe.
I think I have watched all of the videos the guy on reignited put out on this issue as well as many other claiming to have found the root cause. The guy from reignited makes the best case so far and it sounds like he has seen more than a few hemi motors with this issue.
In his other videos he mentioned he has seen this issue much more commonly after the introduction of the VVT (around 2009 ?).
Personally I think the VVT system when operating with the MDS system, low oil volume, and possibly dirty oil may all combine to create oil starvation issues. Another couple contributing factors could be the lifter guides not adequately controlling lifter rotation and the needle bearings in the lifter roller.
Here are some pics of what I found on my daughter's 392:
I am not claiming to know the causes but I think the reignited guy's theories make the most sense. My daughters issue was with a non-MDS cylinder and I can only speak for what I witnessed.
If you go with the MDS delete (cam and lifters) consider using the aluminum MDS plugs with a light film of RTV on the top o-rings and clean the MDS cylinder carefully on the top o-ring surface - oil leaks are not uncommon in this area (ask me how I know - been there done that)